Print ISSN: 2790-0207

Online ISSN: 2790-0215

Author : Mahmood, Susan


ATRA use in Acute Promyelocytic Leukemia

Susan Mahmood

Kirkuk Journal of Medical Sciences, 2022, Volume 10, Issue 1, Pages 64-86
DOI: 10.32894/kjms.2022.174186

Abstract:
        Acute Leukemia is a the result of malignant event or events occurring in early hematopoietic precursor, instead of proliferation and differentiation normally, the affect cells give rise to progency that fail to differentiate and instead continue to proliferate in an uncontrolled fashion.
         Retrospective study, carried between January 2001, and August 2006, Ninety four children ( 15 years of ages) were diagnosed as AML by bone marrow examination (aspirate and sometimes biopsy), twenty two of these children diagnosed as APL, fourteen were treated by chemotherapy and eight of these children treated by ATRA and specific protocol.
      
        M 2 subtype of AML is most common subtype.
 M 3 second most  common  subtype  of  AML  with  peak  age  of
frequency 10-11 years with female predominance.
 Combined ATRA  with  chemotherapy  for  treatment  of  APL
improves survival rate of children.
 The most  common  complication  of  ATRA  encounter  during
treatment was dryness of skin and mucosa.

Obesity and COVID-19

Danaa Bash

Kirkuk Journal of Medical Sciences, 2021, Volume 9, Issue 1, Pages 250-266
DOI: 10.32894/kjms.2021.170298

Abstract
Background: Obesity is a recognized risk factor for severe COVID-19, possibly related to chronic inflammation that disrupts immune and thrombogenic responses to pathogens as well as to impaired lung function from excess weight. Obesity is a common metabolic disease; approximately two in three Iraqi adult participants were overweight/obese.
Aim of Study: The aim of this study is to investigate the association between COVID-19 disease severity and obesity among sample of Iraqi patients.
Patient and methods: A prospective observational study included 609 patients with confirmed Covid-19 infection carried out in Azadi and alShifaa14 hospitals and on outpatient cases in Kirkuk city from 1st November2020 to 30 April 2021 through which BMI was calculated for each patient and correlated with severity.
Results: The study showed that majority of patients (77.9%) were overweight or obese., majority of patients (63.5%) were in sever condition, (24.5%) patients were in mild state, and only 2 patients were critical ill. The males gender were associated with more severe cases (p=0.018). The age was associated with more severity (p=0.0001). BMI showed an association with viral disease severity, in which over weight and obese categories were had more severe symptoms (p=0.0001).
Conclusions: BMI showed an association with COVID-19 Disease status, in which overweight and obese categories were had more severe symptoms (p=0.0001). The study revealed that males gender were associated with more severe cases of COVID-19 disease status (p=0.018).