Background: Coronary heart disease (CHD), the principal manifestation of cardiovascular diseases, is the leading cause of morbidity and mortality worldwide. The World Health Organization (WHO) predicts that by 2020, CHD will become the world‘s most important cause of death, disability and premature death. The major factors are an elevated cholesterol level, hypertension, smoking, genetic factors, a sedentary lifestyle, obesity, and diabetes; and the risk increase with age. Adequate control and well awareness of cardiovascular disease risk factors and health habits are important for preventing CHD. Objective: 1- To make a change of morbidity of CHD by education. 2- To evaluate the health-related quality of life in development of ACS. Patients and Methods: A hospital based case-control study was conducted in the Coronary Care Unit (CCU), which is located in Kirkuk (Azadi Teaching Hospital); from March 2017 to September 2017. The study included 180 cases of coronary heart disease and 180 age and sex matched controls. All the participants were interviewed with special questionnaire form. In addition, the weight and height were measured and the fasting lipid profile was sent to the laboratory of same hospital for all participants. Statistical Package for Social Science (SPSS) version 20.0 was used for data analysis. Results: The males accounts two third of cases, 112(62.2%) in comparison to females 68(37.8 %); 63(35 %) of the cases were in the age group (70-79) years. About (54.7%) of all participants were unemployed, (68.3%) had low education and (38.3%) with low income. The study showed a statistical significant association between the following risk factors and educational level: hypertension, diabetes, dyslipidemia, economic level, occupation, and alcohol consumption. Conclusion: Overall there is a significant relation between educational level and risk of developing CHD. The prevalence of CHD was more common in age group (≥ 60) years and the males were more likely to be affected; hypertension is the most prevalent risk and then diabetes mellitus, occupation respectively.