Background: Gestational diabetes mellitus (GDM) is one of the most common complications of pregnancy. This study aims to evaluate the diagnostic value of first trimester maternal fetuin-A, N-terminal pro atrial natriuretic peptide (pro-ANP), high-sensitivity C-reactive protein (hs-CRP), and fasting plasma glucose (FPG) in the prediction of GDM. Methods: Over 10 months ending in December 2020, 88 low-risk pregnant women attending routine antenatal care in Hawler Maternity Hospital, Erbil, Iraq were enrolled. Maternal venous blood samples were collected for futin-A, pro-ANP, hs-CRP, and FPG. Glucose challenge test (GCT) and oral glucose tolerance test (OGTT) were performed for those with high FPG level. Results: Six of 88 (6.8%) women developed GDM. There was no statistically significant difference between GDM and non-diabetics groups regarding age, gravidity, parity, early pregnancy BMI, and gestational age. There was no significant difference between the 2 groups regarding N-terminal pro-ANP levels but FPG and hs-CRP levels were higher and futin-A levels were lower in the GDM group. Conclusion: The utility of maternal serum hs-CRP, Fetuin-A, and FPG levels as simple-to-do reliable tests to predict the development of GDM.
Jabali,S Abdulateef and Amin,K . (2025). Prediction of Gestational Diabetes Mellitus in The First Trimester: comparison of maternal fetuin-A, N-terminal pro-atrial natriuretic peptide, high-sensitivity C-reactive protein, and fasting glucose levels. Kirkuk Journal of Medical Sciences, 13(1), 46-53. doi: 10.32894/kjms.2025.151075.1108
MLA
Jabali,S Abdulateef, and Amin,K . "Prediction of Gestational Diabetes Mellitus in The First Trimester: comparison of maternal fetuin-A, N-terminal pro-atrial natriuretic peptide, high-sensitivity C-reactive protein, and fasting glucose levels", Kirkuk Journal of Medical Sciences, 13, 1, 2025, 46-53. doi: 10.32894/kjms.2025.151075.1108
HARVARD
Jabali S Abdulateef, Amin K. (2025). 'Prediction of Gestational Diabetes Mellitus in The First Trimester: comparison of maternal fetuin-A, N-terminal pro-atrial natriuretic peptide, high-sensitivity C-reactive protein, and fasting glucose levels', Kirkuk Journal of Medical Sciences, 13(1), pp. 46-53. doi: 10.32894/kjms.2025.151075.1108
CHICAGO
S Abdulateef Jabali and K Amin, "Prediction of Gestational Diabetes Mellitus in The First Trimester: comparison of maternal fetuin-A, N-terminal pro-atrial natriuretic peptide, high-sensitivity C-reactive protein, and fasting glucose levels," Kirkuk Journal of Medical Sciences, 13 1 (2025): 46-53, doi: 10.32894/kjms.2025.151075.1108
VANCOUVER
Jabali S Abdulateef, Amin K. Prediction of Gestational Diabetes Mellitus in The First Trimester: comparison of maternal fetuin-A, N-terminal pro-atrial natriuretic peptide, high-sensitivity C-reactive protein, and fasting glucose levels. KJMS. 2025;13(1):46-53. doi: 10.32894/kjms.2025.151075.1108
