Document Type : Original research
Authors
1 Anesthesia and Intensive Care Department, Hawler Teaching Hospital, Erbil, IRAQ
2 Anesthesia and Intensive Care Department, Tala’afar Hospital, Nineveh City, IRAQ
Abstract
Background: Using a glycopyrrolate/formoterol combination to manage COPD patients is considered a new method. The objectives of this study are to evaluate the effectiveness of the glycopyrrolate/formoterol combination against formoterol alone in optimizing lung function in moderate and severe COPD patients.
Methods: Twenty patients with chronic obstructive pulmonary disease were of class II and III according to the ASA classification. Patients were prospectively divided into two groups: group 1 was given glycopyrrolate and formoterol metered dose inhalers, and group 2 was given a formoterol nebulizer alone. Optimization of treatment was assessed on the first day, at the second week, and at the fourth week by lung function tests (FEV1 and FVC).
Results: Formoterol alone and a combination of formoterol with glycopyrrolate were well tolerated and optimized lung function. FEV1, FVC, and FEV1/FVC ratio significantly increased (p value<0.001). However, the combination of glycopyrrolate and formoterol had a better effect on lung function (FEV1 and FVC) in comparison to formoterol alone (p value<0.001) in 4 weeks of use.
Conclusion: Glycopyrrolate/formoterol metered dose inhaler is more effective in the optimization of the condition of patients with COPD disease than a formoterol nebulizer alone.
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